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Active Recombinant Human KMT2E protein, GST-tagged

Cat.No. : KMT2E-192H
Product Overview : Recombinant Human KMT2E(1-548 aa) fused with GST tag at N-terminal was expressed in Insect cells.
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  • Gene Information
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Description : Mixed-lineage leukemia protein 5 (MLL5) plays a key regulatory role in hematopoiesis by mediating mono- or demethylation of lysine-4 of histone H3. MLL5 can associate with host cell factor-1 (HCF-1) and be recruited to E2F1-responsive promoters, and thus promotes cell cycle progression. Isoform NKp44L acts as cellular ligand for a natural cytotoxicity receptor, which is critical for NK cell-mediated innate immunity.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 250 nmol/min/mg
Molecular Mass : 100 kDa
Protein length : 1-548 aa
Purity : >90%
Applications : Methyltransferase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : KMT2E lysine methyltransferase 2E [ Homo sapiens ]
Official Symbol : KMT2E
Synonyms : MLL5; NKp44L; HDCMC04P; histone-lysine N-methyltransferase MLL5; lysine (K)-specific methyltransferase 2E; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 5
Gene ID : 55904
mRNA Refseq : NM_182931
Protein Refseq : NP_891847
UniProt ID : Q8IZD2
Chromosome Location : 7q22.3
Pathway : Chromatin modifying enzymes, organism-specific biosystem; Lysine degradation, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
Function : enzyme binding; transcription coactivator activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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