| Description : |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| Protein length : |
564 amino acids |
| Molecular Weight : |
87.780kDa inclusive of tags |
| Source : |
Wheat germ |
| Tissue specificity : |
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath. |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSR SRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAIS GGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAG GFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQRVR AEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQE QGTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELR NMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYMN KVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVL SMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKY EELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKK QCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQD LARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEG VGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSG LGVGGGFSSSSGRATGGGLSSVGGGSSTIKYTTTSSSSRK SYKH |
| Sequence Similarities : |
Belongs to the intermediate filament family. |
