"LCMT1" Related Products


Recombinant Human LCMT1 protein, GST-tagged, Active

Cat.No.: LCMT1-187H
Product Overview: Recombinant Human LCMT1 fused with GST tag at N-terminal was expressed in Insect cells.
Description: Leucine carboxyl methyltransferase 1 (LCMT1) exclusively methylates the carboxyl group of leucine-309 in the catalytic subunit of protein phosphatase 2A. LCMT1 is essential for normal progression through mitosis and cell survival. Knocking-down LCMT1 leads to reduced formation of PP2A heterodimers and increased apoptosis. LCMT1 also regulates the association of PP2A and its substrate, Tau protein, with plasma membrane in neuroblastoma cells. Decreased level of PP2A methylation is found in Alzheimer disease.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 480 nmol/min/mg
Molecular Mass: 63 kDa
Purity: >95%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: LCMT1 leucine carboxyl methyltransferase 1 [ Homo sapiens ]
Official Symbol: LCMT1
Synonyms: LCMT1; leucine carboxyl methyltransferase 1; CGI 68; PPMT1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; LCMT; CGI-68;
Gene ID: 51451
mRNA Refseq: NM_016309
Protein Refseq: NP_057393
MIM: 610286
UniProt ID: Q9UIC8
Chromosome Location: 16p12.1
Function: S-adenosylmethionine-dependent methyltransferase activity; protein C-terminal carboxyl O-methyltransferase activity; protein binding; transferase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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