Recombinant Human LDHB Protein, MYC/DDK-tagged

• Cat.No.: LDHB-424H
• Product Overview: Recombinant human LDHB protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 36.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: lactate dehydrogenase B [ Homo sapiens ]
• Official Symbol: LDHB
• Synonyms: HEL-S-281; LDH-B; LDH-H; LDHBD; TRG-5
• Gene ID: 3945
• mRNA Refseq: NM_001174097.1
• Protein Refseq: NP_001167568.1
• MIM: 150100
• UniProt ID: P07195

Reviews

04/27/2022

I highly endorse the utilization of the LDHB Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.

11/05/2020

Their expertise has proven instrumental in overcoming obstacles and has greatly contributed to the success of my research endeavors.

10/14/2016

Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.

Q&As

Does LDHB play a role in heart disease?

Yes, LDHB dysregulation is associated with heart conditions like myocardial infarction (heart attack) and heart failure.

Are there specific populations more susceptible to LDHB-related conditions?

While LDHB-related diseases can affect anyone, some genetic predispositions may heighten the risk in certain ethnic groups.

How is LDHB protein clinically relevant?

It plays a role in various physiological processes and has implications in disease states.

How does LDHB contribute to cancer?

In certain cancers, elevated LDHB levels promote tumor growth by supporting the Warburg effect, where cancer cells use glycolysis even in the presence of oxygen.

Can LDHB be a therapeutic target in cancer treatment?

Targeting LDHB shows promise in inhibiting cancer growth, and there's ongoing research in developing drugs that target this enzyme.