| Description : |
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
49.4 kDa |
| AA Sequence : |
MVWKVAVFLSVALGIGAIPIDDPED GGKHWVVIVAGSNGWYNYRHQADAC HAYQIIHRNGIPDEQIVVMMYDDIA YSEDNPTPGIVINRPNGTDVYQGVP KDYTGEDVTPQNFLAVLRGDAEAVK GIGSGKVLKSGPQDHVFIYFTDHGS TGILVFPNEDLHVKDLNETIHYMYK HKMYRKMVFYIEACESGSMMNHLPD NINVYATTAANPRESSYACYYDEKR STYLGDWYSVNWMEDSDVEDLTKET LHKQYHLVKSHTNTSHVMQYGNKTI STMKVMQFQGMKRKASSPVPLPPVT HLDLTPSPDVPLTIMKRKLMNTNDL EESRQLTEEIQRHLDARHLIEKSVR KIVSLLAASEAEVEQLLSERAPLTG HSCYPEALLHFRTHCFNWHSPTYEY ALRHLYVLVNLCEKPYPLHRIKLSM DHVCLGHYSGPTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
