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Recombinant Human LGR5 Protein (22-561 aa), His-Myc-tagged

Cat.No. : LGR5-2271H
Product Overview : Recombinant Human LGR5 Protein (22-561 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Protein Description: Partial.
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Description : Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Source : E. coli
Species : Human
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 65.4 kDa
Protein length : 22-561 aa
AA Sequence : GSSPRSGVLLRGCPTHCHCEPDGRM LLRVDCSDLGLSELPSNLSVFTSYL DLSMNNISQLLPNPLPSLRFLEELR LAGNALTYIPKGAFTGLYSLKVLML QNNQLRHVPTEALQNLRSLQSLRLD ANHISYVPPSCFSGLHSLRHLWLDD NALTEIPVQAFRSLSALQAMTLALN KIHHIPDYAFGNLSSLVVLHLHNNR IHSLGKKCFDGLHSLETLDLNYNNL DEFPTAIRTLSNLKELGFHSNNIRS IPEKAFVGNPSLITIHFYDNPIQFV GRSAFQHLPELRTLTLNGASQITEF PDLTGTANLESLTLTGAQISSLPQT VCNQLPNLQVLDLSYNLLEDLPSFS VCQKLQKIDLRHNEIYEIKVDTFQQ LLSLRSLNLAWNKIAIIHPNAFSTL PSLIKLDLSSNLLSSFPITGLHGLT HLKLTGNHALQSLISSENFPELKVI EMPYAYQCCAFGVCENAYKISNQWN KGDNSSMDDLHKKDAGMFQAQDERD LEDFLLDFEEDLKALHSVQCSPSPG PFKPCEHLLDGWLIR
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Gene Name : LGR5 leucine-rich repeat containing G protein-coupled receptor 5 [ Homo sapiens ]
Official Symbol : LGR5
Synonyms : LGR5; FEX; HG38; G-protein coupled receptor 49; GPR49; GPR67; GRP49; MGC117008;
Gene ID : 8549
mRNA Refseq : NM_003667
Protein Refseq : NP_003658
MIM : 606667
UniProt ID : O75473

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of LGR5 in stem cell biology? 10/15/2022

LGR5, a G protein-coupled receptor, is crucial for the maintenance and proliferation of adult stem cells.

How do genetic variations in LGR5 affect tissue homeostasis? 08/28/2022

Genetic mutations in LGR5 can disrupt normal stem cell function and tissue maintenance.

How does LGR5 contribute to tissue regeneration? 08/02/2021

It plays a key role in promoting tissue regeneration by signaling stem cells to divide and differentiate.

What role does LGR5 play in Wnt signaling? 10/23/2020

LGR5 acts as a co-receptor in the Wnt signaling pathway, essential for regulating stem cell growth.

What is the impact of altered LGR5 activity on cancer development? 05/07/2018

Altered LGR5 activity is associated with the growth of certain cancers, particularly colorectal cancer.

How does LGR5 interact with other components in the Wnt pathway? 12/29/2017

LGR5 works alongside Wnt ligands and receptors, enhancing Wnt-mediated signaling in stem cells.

What potential therapeutic applications arise from targeting LGR5 in regenerative medicine and oncology? 08/01/2017

Targeting LGR5 offers potential for both regenerating tissues in degenerative diseases and targeting cancer stem cells.

Customer Reviews (3)

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09/06/2021

    Critical for decision-making, enhances our research quality.

    01/29/2020

      Enhances research credibility, critical for research integrity.

      06/08/2019

        Efficiency and precision, integral to our research.

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