Recombinant Human LGR5 protein, His-Avi-tagged

• Cat.No.: LGR5-549H
• Product Overview: Human LGR5 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Gly22-Ile560.

Specification

• Description: Lgr5 (leucine-rich repeat G-protein coupled receptor 5), also called GPR49, is a seven-transmembrane glycoprotein receptor in the Lgr family of cell surface receptors. Lgr5 is receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 63.1 kDa.
• Protein length: Gly22-Ile560
• Endotoxin: Less than 1EU per ug by the LAL method.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: LGR5
• Official Symbol: LGR5
• Synonyms: GRP49; leucine-rich repeat-containing G-protein coupled receptor 5; FEX; G protein-coupled receptor 49; GPR49; GPR49G-protein coupled receptor HG38; GPR67; G-protein coupled receptor 49; G-protein coupled receptor 67; HG38; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5;Lgr5; MGC117008; orphan G protein-coupled receptor HG38
• Gene ID: 8549
• mRNA Refseq: NM_003667.2
• Protein Refseq: NP_003658.1
• MIM: 606667
• UniProt ID: O75473

Reviews

09/06/2021

Critical for decision-making, enhances our research quality.

01/29/2020

Enhances research credibility, critical for research integrity.

06/08/2019

Efficiency and precision, integral to our research.

Q&As

What is the primary role of LGR5 in stem cell biology?

LGR5, a G protein-coupled receptor, is crucial for the maintenance and proliferation of adult stem cells.

How do genetic variations in LGR5 affect tissue homeostasis?

Genetic mutations in LGR5 can disrupt normal stem cell function and tissue maintenance.

How does LGR5 contribute to tissue regeneration?

It plays a key role in promoting tissue regeneration by signaling stem cells to divide and differentiate.

What role does LGR5 play in Wnt signaling?

LGR5 acts as a co-receptor in the Wnt signaling pathway, essential for regulating stem cell growth.

What is the impact of altered LGR5 activity on cancer development?

Altered LGR5 activity is associated with the growth of certain cancers, particularly colorectal cancer.

How does LGR5 interact with other components in the Wnt pathway?

LGR5 works alongside Wnt ligands and receptors, enhancing Wnt-mediated signaling in stem cells.

What potential therapeutic applications arise from targeting LGR5 in regenerative medicine and oncology?

Targeting LGR5 offers potential for both regenerating tissues in degenerative diseases and targeting cancer stem cells.