Recombinant Human LILRA4 protein, His-Avi-tagged

• Cat.No.: LILRA4-901H
• Product Overview: Human LILRA4 Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains Glu24-Asn446.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: Glu24-Asn446
• Description: LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 49.5 kDa .Due to glycosylation, the protein migrates to 60-75 KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0.2 EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: LILRA4 leukocyte immunoglobulin like receptor A4 [ Homo sapiens (human) ]
• Official Symbol: LILRA4
• Synonyms: CD85 antigen-like family member G; CD85g antigen; CD85g; ILT7; ILT-7; ILT7MGC129598; Immunoglobulin-like transcript 7; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member4; LILRA4; MGC129597
• Gene ID: 23547
• mRNA Refseq: NM_012276.5
• Protein Refseq: NP_036408.4
• MIM: 607517
• UniProt ID: P59901