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Recombinant Human LIMK2 Protein, GST/His-tagged

Cat.No. : LIMK2-382H
Product Overview : Recombinant Human LIMK2, transcript variant 1, fused with N-terminal GST and C-terminal His was expressed in E. coli.
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  • Gene Information
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Description : There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : GST/His
Form : 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Molecular Mass : 103.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : LIMK2 LIM domain kinase 2 [ Homo sapiens ]
Official Symbol : LIMK2
Synonyms : LIMK2; LIM domain kinase 2;
Gene ID : 3985
mRNA Refseq : NM_001031801
Protein Refseq : NP_001026971
MIM : 601988
UniProt ID : P53671

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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