Recombinant Human LMOD3 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human LMOD3 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : LMOD3-1028H
Product Overview : LMOD3 MS Standard C13 and N15-labeled recombinant protein (NP_938012) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 64.7 kDa
AA Sequence : MSEHSRNSDQ EELLDEEINE DEILANLSAE ELKELQSEME VMAPDPSLPV GMIQKDQTDK PPTGNFNHKS LVDYMYWEKA SRRMLEEERV PVTFVKSEEK TQEEHEEIEK RNKNMAQYLK EKLNNEIVAN KRESKGSSNI QETDEEDEEE EDDDDDDEGE DDGEESEETN REEEGKAKEQ IRNCENNCQQ VTDKAFKEQR DRPEAQEQSE KKISKLDPKK LALDTSFLKV STRPSGNQTD LDGSLRRVRK NDPDMKELNL NNIENIPKEM LLDFVNAMKK NKHIKTFSLA NVGADENVAF ALANMLRENR SITTLNIESN FITGKGIVAI MRCLQFNETL TELRFHNQRH MLGHHAEMEI ARLLKANNTL LKMGYHFELP GPRMVVTNLL TRNQDKQRQK RQEEQKQQQL KEQKKLIAML ENGLGLPPGM WELLGGPKPD SRMQEFFQPP PPRPPNPQNV PFSQRSEMMK KPSQAPKYRT DPDSFRVVKL KRIQRKSRMP EAREPPEKTN LKDVIKTLKP VPRNRPPPLV EITPRDQLLN DIRHSSVAYL KPVQLPKELA TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : LMOD3 leiomodin 3 [ Homo sapiens (human) ]
Official Symbol : LMOD3
Synonyms : LMOD3; leiomodin 3; NEM10; leiomodin-3; leiomodin 3 (fetal); leiomodin, fetal form
Gene ID : 56203
mRNA Refseq : NM_198271
Protein Refseq : NP_938012
MIM : 616112
UniProt ID : Q0VAK6

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