| Description : |
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
98.5 kDa |
| AA Sequence : |
MNYVGQLAGQVFVTVKELYKGLNPA TLSGCIDIIVIRQPNGNLQCSPFHV RFGKMGVLRSREKVVDIEINGESVD LHMKLGDNGEAFFVQETDNDQEVIP MHLATSPILSEGASRMECQLKRGSV DRMRGLDPSTPAQVIAPSETPSSSS VVKKRRKRRRKSQLDSLKRDDNMNT SEDEDMFPIEMSSDEAMELLESSRT LPNDIPPFQDDIPEENLSLAVIYPQ SASYPNSDREWSPTPSPSGSRPSTP KSDSELVSKSTERTGQKNPEMLWLW GELPQAAKSSSPHKMKESSPLSSRK ICDKSHFQAIHSESSDTFSDQSPTL VGGALLDQNKPQTEMQFVNEEDLET LGAAAPLLPMIEELKPPSASVVQTA NKTDSPSRKRDKRSRHLGADGVYLD DLTDMDPEVAALYFPKNGDPSGLAK HASDNGARSANQSPQSVGSSGVDSG VESTSDGLRDLPSIAISLCGGLSDH REITKDAFLEQAVSYQQFVDNPAII DDPNLVVKIGSKYYNWTTAAPLLLA MQAFQKPLPKATVESIMRDKMPKKG GRWWFSWRGRNTTIKEESKPEQCLA GKAHSTGEQPPQLSLATRVKHESSS SDEERAAAKPSNAGHLPLLPNVSYK KTLRLTSEQLKSLKLKNGPNDVVFS VTTQYQGTCRCEGTIYLWNWDDKVI ISDIDGTITRSDTLGHILPTLGKDW THQGIAKLYHKVSQNGYKFLYCSAR AIGMADMTRGYLHWVNERGTVLPQG PLLLSPSSLFSALHREVIEKKPEKF KVQCLTDIKNLFFPNTEPFYAAFGN RPADVYSYKQVGVSLNRIFTVNPKG ELVQEHAKTNISSYVRLCEVVDHVF PLLKRSHSSDFPCSDTFSNFTFWRE PLPPFENQDIHSASATRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
