Recombinant Human LRP10 protein, Fc-tagged
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|Product Overview :||Recombinant Human LRP10 (His17-Lys440) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||Low-density lipoprotein receptor-related protein 10 (LRP10), a member of the LDLR family, is a single-pass type I membrane protein, which contains two CUB domains and four LDL-receptor class A domains. As a probable receptor, LRP10 is involved in the internalization of lipophilic molecules or signal transduction. LRP10 may be involved in the uptake of lipoprotein APOE in liver. Furthermore, Deletion of the extracellular domain of LRP10 negated its inhibitory effect. It sugested that LRP10 may interfere with the formation of the beta-catenin/TCF complex and its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway. LRP10 has been improved to play a significant role in the brain physiology other than lipoprotein metabolism.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||His17|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 72.7 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||His17-Lys440|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>90% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of LRP10-978H :||
Human LRP-10, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
|Gene Name :||LRP10|
|Official Symbol :||LRP10|
|Synonyms :||LRP10; low density lipoprotein receptor-related protein 10; low-density lipoprotein receptor-related protein 10; DKFZP564C1940; MGC8675; LRP-10; LRP9; MST087; MSTP087; MGC142274; MGC142276; DKFZp564C1940|
|Gene ID :||26020|
|mRNA Refseq :||NM_014045|
|Protein Refseq :||NP_054764|
|UniProt ID :||Q7Z4F1|
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