| Description : |
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
179 kDa |
| AA Sequence : |
MEAAPPGPPWPLLLLLLLLLALCGC PAPAAASPLLLFANRRDVRLVDAGG VKLESTIVVSGLEDAAAVDFQFSKG AVYWTDVSEEAIKQTYLNQTGAAVQ NVVISGLVSPDGLACDWVGKKLYWT DSETNRIEVANLNGTSRKVLFWQDL DQPRAIALDPAHGYMYWTDWGETPR IERAGMDGSTRKIIVDSDIYWPNGL TIDLEEQKLYWADAKLSFIHRANLD GSFRQKVVEGSLTHPFALTLSGDTL YWTDWQTRSIHACNKRTGGKRKEIL SALYSPMDIQVLSQERQPFFHTRCE EDNGGCSHLCLLSPSEPFYTCACPT GVQLQDNGRTCKAGAEEVLLLARRT DLRRISLDTPDFTDIVLQVDDIRHA IAIDYDPLEGYVYWTDDEVRAIRRA YLDGSGAQTLVNTEINDPDGIAVDW VARNLYWTDTGTDRIEVTRLNGTSR KILVSEDLDEPRAIALHPVMGLMYW TDWGENPKIECANLDGQERRVLVNA SLGWPNGLALDLQEGKLYWGDAKTD KIEVINVDGTKRRTLLEDKLPHIFG FTLLGDFIYWTDWQRRSIERVHKVK ASRDVIIDQLPDLMGLKAVNVAKVV GTNPCADRNGGCSHLCFFTPHATRC GCPIGLELLSDMKTCIVPEAFLVFT SRAAIHRISLETNNNDVAIPLTGVK EASALDFDVSNNHIYWTDVSLKTIS RAFMNGSSVEHVVEFGLDYPEGMAV DWMGKNLYWADTGTNRIEVARLDGQ FRQVLVWRDLDNPRSLALDPTKGYI YWTEWGGKPRIVRAFMDGTNCMTLV DKVGRANDLTIDYADQRLYWTDLDT NMIESSNMLGQERVVIADDLPHPFG LTQYSDYIYWTDWNLHSIERADKTS GRNRTLIQGHLDFVMDILVFHSSRQ DGLNDCMHNNGQCGQLCLAIPGGHR CGCASHYTLDPSSRNCSPPTTFLLF SQKSAISRMIPDDQHSPDLILPLHG LRNVKAIDYDPLDKFIYWVDGRQNI KRAKDDGTQPFVLTSLSQGQNPDRQ PHDLSIDIYSRTLFWTCEATNTINV HRLSGEAMGVVLRGDRDKPRAIVVN AERGYLYFTNMQDRAAKIERAALDG TEREVLFTTGLIRPVALVVDNTLGK LFWVDADLKRIESCDLSGANRLTLE DANIVQPLGLTILGKHLYWIDRQQQ MIERVEKTTGDKRTRIQGRVAHLTG IHAVEEVSLEEFSAHPCARDNGGCS HICIAKGDGTPRCSCPVHLVLLQNL LTCGEPPTCSPDQFACATGEIDCIP GAWRCDGFPECDDQSDEEGCPVCSA AQFPCARGQCVDLRLRCDGEADCQD RSDEVDCDAICLPNQFRCASGQCVL IKQQCDSFPDCIDGSDELMCEITKP PSDDSPAHSSAIGPVIGIILSLFVM GGVYFVCQRVVCQRYAGANGPFPHE YVSGTPHVPLNFIAPGGSQHGPFTG IACGKSMMSSVSLMGGRGGVPLYDR NHVTGASSSSSSSTKATLYPPILNP PPSPATDPSLYNMDMFYSSNIPATA RPYRPYIIRGMAPPTTPCSTDVCDS DYSASRWKASKYYLDLNSDSDPYPP PPTPHSQYLSAEDSCPPSPATERSY FHLFPPPPSPCTDSSTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
