Recombinant Human LRRC4 protein, His-tagged


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Recombinant Human LRRC4 protein, His-tagged

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Cat.No. : LRRC4-180H
Product Overview : Recombinant Human LRRC4 protein (Ala39-Lys527), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
Description : LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4/NGL-2 specifically expressed in brain. LRRC4/NGL-2 regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4/NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4/NGL-2 plays a important role for auditory synaptic responses and involved in the suppression of glioma.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 55.6 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 489
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >92% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of LRRC4-180H :

Human LRRC4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

Gene Name : LRRC4
Official Symbol : LRRC4
Synonyms : LRRC4; leucine rich repeat containing 4; leucine-rich repeat-containing protein 4; NAG14; netrin-G2 ligand; leucine-rich repeat-containing 4; brain tumor-associated protein BAG; brain tumor associated protein LRRC4; nasopharyngeal carcinoma-associated gene 14 protein; NGL-2; MGC133342; MGC133343
Gene ID : 64101
mRNA Refseq : NM_022143
Protein Refseq : NP_071426
MIM : 610486
UniProt ID : Q9HBW1
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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