Recombinant Human LRRC4 protein, His-tagged

• Cat.No.: LRRC4-180H
• Product Overview: Recombinant Human LRRC4 protein (Ala39-Lys527), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4/NGL-2 specifically expressed in brain. LRRC4/NGL-2 regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4/NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4/NGL-2 plays a important role for auditory synaptic responses and involved in the suppression of glioma.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 55.6 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: 489
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: LRRC4
• Official Symbol: LRRC4
• Synonyms: LRRC4; leucine rich repeat containing 4; leucine-rich repeat-containing protein 4; NAG14; netrin-G2 ligand; leucine-rich repeat-containing 4; brain tumor-associated protein BAG; brain tumor associated protein LRRC4; nasopharyngeal carcinoma-associated gene 14 protein; NGL-2; MGC133342; MGC133343
• Gene ID: 64101
• mRNA Refseq: NM_022143
• Protein Refseq: NP_071426
• MIM: 610486
• UniProt ID: Q9HBW1