| Description : |
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
92.4 kDa |
| AA Sequence : |
MIPVTEFRQFSEQQPAFRVLKPWWD VFTDYLSVAMLMIGVFGCTLQVMQD KIICLPKRVQPAQNHSSLSNVSQAV ASTTPLPPPKPSPANPITVEMKGLK TDLDLQQYSFINQMCYERALHWYAK YFPYLVLIHTLVFMLCSNFWFKFPG SSSKIEHFISILGKCFDSPWTTRAL SEVSGEDSEEKDNRKNNMNRSNTIQ SGPEGSLVNSQSLKSIPEKFVVDKS TAGALDKKEGEQAKALFEKVKKFRL HVEEGDILYAMYVRQTVLKVIKFLI IIAYNSALVSKVQFTVDCNVDIQDM TGYKNFSCNHTMAHLFSKLSFCYLC FVSIYGLTCLYTLYWLFYRSLREYS FEYVRQETGIDDIPDVKNDFAFMLH MIDQYDPLYSKRFAVFLSEVSENKL KQLNLNNEWTPDKLRQKLQTNAHNR LELPLIMLSGLPDTVFEITELQSLK LEIIKNVMIPATIAQLDNLQELSLH QCSVKIHSAALSFLKENLKVLSVKF DDMRELPPWMYGLRNLEELYLVGSL SHDISRNVTLESLRDLKSLKILSIK SNVSKIPQAVVDVSSHLQKMCIHND GTKLVMLNNLKKMTNLTELELVHCD LERIPHAVFSLLSLQELDLKENNLK SIEEIVSFQHLRKLTVLKLWHNSIT YIPEHIKKLTSLERLSFSHNKIEVL PSHLFLCNKIRYLDLSYNDIRFIPP EIGVLQSLQYFSITCNKVESLPDEL YFCKKLKTLKIGKNSLSVLSPKIGN LLFLSYLDVKGNHFEILPPELGDCR ALKRAGLVVEDALFETLPSDVREQM KTETRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
