Recombinant Human Lymphocyte Antigen 96, His-tagged

• Cat.No.: LY96-1548H
• Product Overview: Recombinant Human LY96 was expressed inE.Coliusing an N-terminal His tag. MW= 22 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
• Sequence: 1-160.
• Purity: 95%.
• Specific Activity: n/aH.
• Applications: E, WB, MS.
• Buffer: 1X PBS containing 0.1% SDS.
• Storage: Store at -70?C. As with any protein, exposing LY96 recombinant protein to repeated freeze/thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• SDS-PAGE: SDS PAGE Analysis of LY96 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining.

Gene Information

• Gene Name: LY96 lymphocyte antigen 96 [ Homo sapiens ]
• Synonyms: LY96; lymphocyte antigen 96; MD2; MD-2; myeloid differentiation protein-2; MD-2 protein
• Gene ID: 23643
• mRNA Refseq: NM_015364
• Protein Refseq: NP_056179
• MIM: 605243
• UniProt ID: Q9Y6Y9
• Chromosome Location: 8q21.11
• Pathway: Pathogenic Escherichia coli infection; Toll-like receptor signaling pathway; Signaling in Immune system
• Function: coreceptor activity; lipopolysaccharide receptor activity; protein binding