Recombinant Human LYPLA1 Protein, His-tagged

• Cat.No.: LYPLA1-7740H
• Product Overview: Recombinant protein of human full length lysophospholipase I (LYPLA1) with N-terminal His tag was expressed in E.coli.

Specification

• Description: This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 25.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol

Gene Information

• Gene Name: LYPLA1 lysophospholipase 1 [ Homo sapiens (human) ]
• Official Symbol: LYPLA1
• Synonyms: LYPLA1; lysophospholipase 1; APT1; LPL1; APT-1; LPL-I; hAPT1; acyl-protein thioesterase 1; lysoPLA I; lysophospholipase I; lysophospholipid-specific lysophospholipase; EC 3.1.1.5; EC 3.1.2.-
• Gene ID: 10434
• mRNA Refseq: NM_006330
• Protein Refseq: NP_006321
• MIM: 605599
• UniProt ID: Q6IAQ1

Reviews

07/29/2020

Reliable data source, highly recommended for research credibility.

05/24/2018

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11/03/2017

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Q&As

How do genetic variations in LYPLA1 affect cell function?

Genetic mutations in LYPLA1 can lead to dysregulation of lipid metabolism and protein modification.

What is the impact of altered LYPLA1 activity on disease development?

Altered LYPLA1 activity is linked to various diseases, including metabolic and neurodegenerative disorders.

What potential therapeutic applications arise from targeting LYPLA1 in metabolic disorders?

Targeting LYPLA1 could provide new strategies for treating diseases related to lipid metabolism and protein modification.

How does LYPLA1 interact with other enzymes in lipid metabolism?

LYPLA1 works with other lipid metabolism enzymes, coordinating lipid modification and signaling pathways.

What is the primary role of LYPLA1 in cellular metabolism?

LYPLA1, a lysophospholipase, is involved in lipid metabolism, crucial for maintaining cellular lipid balance.

What role does LYPLA1 play in signal transduction?

LYPLA1 is involved in signal transduction processes by modulating the lipidation status of signaling proteins.

How does LYPLA1 contribute to protein modification?

It plays a role in protein modification, particularly in depalmitoylation, affecting protein function and localization.