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Active Recombinant Human MADCAM1 protein, His-tagged

Cat.No. : MADCAM1-3982H
Product Overview : Recombinant Human MADCAM1 protein(Gln 19 - Gln 317), fused with His tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Bio-activity : Human MAdCAM-1, His Tag immobilized on CM5 Chip can bind Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free with an affinity constant of 0.227 μM as determined in a SPR assay (Biacore 8K).
Molecular Mass : This protein carries a polyhistidine tag at the C-terminusThe protein has a calculated MW of 33.3 kDa. The protein migrates as 46-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein Length : Gln 19 - Gln 317
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE. >95% as determined by SEC-MALS.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : MADCAM1 mucosal vascular addressin cell adhesion molecule 1 [ Homo sapiens ]
Official Symbol : MADCAM1
Synonyms : MADCAM1; mucosal vascular addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule 1; MACAM1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1;
Gene ID : 8174
mRNA Refseq : NM_130760
Protein Refseq : NP_570116
MIM : 102670
UniProt ID : Q13477

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MADCAM1 be targeted for other medical conditions? 01/31/2023

While its primary application is in IBD, researchers are exploring the potential of MADCAM1 in other inflammatory conditions.

How effective is vedolizumab in treating IBD? 10/21/2019

Vedolizumab has shown efficacy in inducing and maintaining remission in patients with moderate to severe IBD.

Are there any side effects associated with vedolizumab? 06/21/2018

Common side effects may include headache, abdominal pain, and respiratory tract infections, but it is generally considered a well-tolerated treatment.

What are the challenges in developing MADCAM1-targeted therapies? 06/01/2017

Challenges include finding the right balance between immune suppression and maintaining immune function and addressing potential side effects.

Can MADCAM1 be used as a biomarker for disease activity in IBD? 08/09/2016

MADCAM1 levels can be measured and used as a biomarker to assess disease activity and response to treatment in IBD patients.

Customer Reviews (3)

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04/27/2022

    Reputable manufacturers often provide technical support to researchers using MADCAM1 protein.

    11/08/2018

      Manufacturers can ensure high-quality production of MADCAM1 protein, maintaining its purity and integrity.

      10/14/2016

        This guarantees the reliability and reproducibility of research findings and eliminates potential issues arising from impurities or contamination.

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