Recombinant Human MAPK8IP1 Protein, MYC/DDK-tagged

Cat.No. : MAPK8IP1-378H
Product Overview : Recombinant human MAPK8IP1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 77.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : mitogen-activated protein kinase 8 interacting protein 1 [ Homo sapiens ]
Official Symbol : MAPK8IP1
Synonyms : IB1; JIP-1; JIP1; PRKM8IP
Gene ID : 9479
mRNA Refseq : NM_005456.3
Protein Refseq : NP_005447.1
MIM : 604641
UniProt ID : Q6NUQ9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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