Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

Recombinant Human matrix metallopeptidase 3 Protein, His&Flag tagged

Cat.No. : MMP3-218H
Product Overview : Recombinant human MMP3 protein (P08254) (Tyr18-Cys 477) with both His, Flag tag at the C-terminus was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
Source : HEK293
Species : Human
Tag : C-His&Flag
Protein length : 18-477aa
Molecular Mass : 54.9 kDa
Endotoxin : Less than 1.0 EU/μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Reconstitution : Reconstitute at 250 μg/mL in sterile water.
Gene Name : MMP3 matrix metallopeptidase 3 [ Homo sapiens (human) ]
Official Symbol : MMP3
Synonyms : MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase), STMY, STMY1; stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104;
Gene ID : 4314
mRNA Refseq : NM_002422
Protein Refseq : NP_002413
MIM : 185250
UniProt ID : P08254

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
12/05/2020

    Critical expertise in protein engineering, a trusted partner in research.

    03/21/2020

      Swift and reliable protein sequencing, a key asset for our work.

      01/22/2020

        High-quality protein crystallography services, consistently delivers exceptional outcomes.

        Q&As (7)

        Ask a question
        How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling? 10/21/2022

        MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

        What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation? 07/04/2022

        MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

        How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions? 10/19/2021

        Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

        How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation? 07/01/2021

        MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

        What role does MMP3 play in the progression of arthritis and joint degeneration? 09/03/2019

        MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

        What are the mechanisms by which MMP3 modulates inflammatory responses? 06/13/2019

        MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

        How does MMP3 contribute to wound healing and tissue repair processes? 12/31/2018

        MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.

        Ask a Question for All MMP3 Products

        Required fields are marked with *

        My Review for All MMP3 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2025 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends