Recombinant Human MBNL2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MBNL2-5823H
• Product Overview: MBNL2 MS Standard C13 and N15-labeled recombinant protein (NP_997187) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.
• Molecular Mass: 39.4 kDa
• AA Sequence: MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQHAAFIPTDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTACTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MBNL2 muscleblind-like splicing regulator 2 [ Homo sapiens (human) ]
• Official Symbol: MBNL2
• Synonyms: MBNL2; muscleblind-like splicing regulator 2; muscleblind like 2 (Drosophila); muscleblind-like protein 2; MBLL; MBLL39; muscleblind-like 2; muscleblind-like protein 1; muscleblind-like protein-like 39; PRO2032; RP11-128N14.1; MGC120625; MGC120626; MGC120628; DKFZp781H1296
• Gene ID: 10150
• mRNA Refseq: NM_207304
• Protein Refseq: NP_997187
• MIM: 607327
• UniProt ID: Q5VZF2