Recombinant Human MERTK protein(Glu578-Tyr872), His&GST-tagged

• Cat.No.: MERTK-1352H
• Product Overview: Recombinant Human MERTK (Q12866)(Glu 578-Tyr 872) was expressed in Insect Cells, fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Specification

• Source: Insect Cells
• Species: Human
• Tag: His&GST
• Protein length: Glu578-Tyr872
• Form: Supplied as sterile 50mM Tris, 100mM NaCl, pH 7.4, 20% gly, 0.3mM DTT.
• Molecular Mass: The recombinant human MERTK (aa578-872)/GST chimera consists of 532 amino acids and has a calculated molecular mass of 62 kDa. It migRates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 92 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ]
• Official Symbol: MERTK
• Synonyms: MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349
• Gene ID: 10461
• mRNA Refseq: NM_006343
• Protein Refseq: NP_006334
• MIM: 604705
• UniProt ID: Q12866

Reviews

04/08/2022

Fast shipping and excellent service. This product is a lab essential.

06/15/2020

Highly recommend for quality and prompt delivery.

03/25/2018

Exceptional product, outstanding customer service!

Q&As

In cancer biology, how does MERTK contribute to tumor progression and metastasis, and are there potential therapeutic strategies targeting MERTK in cancer treatment?

MERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.

How does the Gas6-MERTK signaling axis contribute to cellular processes beyond phagocytosis, and what downstream effectors are activated upon MERTK activation?

The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.

In neurobiology, what is the role of MERTK in microglial phagocytosis and synaptic pruning, and how does this impact neural circuitry development?

MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.

What is the role of MERTK in the regulation of immune responses, and how does its dysregulation contribute to autoimmune disorders and inflammatory diseases?

MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.

What experimental techniques are commonly used to study MERTK, including its ligands, downstream signaling pathways, and cellular functions?

Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.