Recombinant Human MERTK protein, His-tagged

Cat.No. : MERTK-149H
Product Overview : Recombinant Human MERTK protein(Q1RMG3)(Met1-Ala323), fused with C-terminal His tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : C-His
Protein length : Met1-Ala323
Form : Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Molecular Mass : 36 KDa
Endotoxin : < 1 EU/μg as determined by LAL test.
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Reconstitution : Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ]
Official Symbol : MERTK
Synonyms : MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349;
Gene ID : 10461
mRNA Refseq : NM_006343
Protein Refseq : NP_006334
MIM : 604705
UniProt ID : Q12866

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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04/08/2022

    Fast shipping and excellent service. This product is a lab essential.

    06/15/2020

      Highly recommend for quality and prompt delivery.

      03/25/2018

        Exceptional product, outstanding customer service!

        Q&As (5)

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        In cancer biology, how does MERTK contribute to tumor progression and metastasis, and are there potential therapeutic strategies targeting MERTK in cancer treatment? 02/18/2022

        MERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.

        How does the Gas6-MERTK signaling axis contribute to cellular processes beyond phagocytosis, and what downstream effectors are activated upon MERTK activation? 07/27/2021

        The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.

        In neurobiology, what is the role of MERTK in microglial phagocytosis and synaptic pruning, and how does this impact neural circuitry development? 03/10/2020

        MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.

        What is the role of MERTK in the regulation of immune responses, and how does its dysregulation contribute to autoimmune disorders and inflammatory diseases? 09/03/2019

        MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.

        What experimental techniques are commonly used to study MERTK, including its ligands, downstream signaling pathways, and cellular functions? 12/04/2018

        Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.

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