Recombinant Human MERTK protein, His-tagged
Cat.No. : | MERTK-149H |
Product Overview : | Recombinant Human MERTK protein(Q1RMG3)(Met1-Ala323), fused with C-terminal His tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | C-His |
Protein length : | Met1-Ala323 |
Form : | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
Molecular Mass : | 36 KDa |
Endotoxin : | < 1 EU/μg as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Reconstitution : | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens ] |
Official Symbol : | MERTK |
Synonyms : | MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349; |
Gene ID : | 10461 |
mRNA Refseq : | NM_006343 |
Protein Refseq : | NP_006334 |
MIM : | 604705 |
UniProt ID : | Q12866 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewFast shipping and excellent service. This product is a lab essential.
Highly recommend for quality and prompt delivery.
Exceptional product, outstanding customer service!
Q&As (5)
Ask a questionMERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.
The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.
MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.
MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.
Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.
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