| Description : |
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
102.7 kDa |
| Protein Length : |
1390 |
| AA Sequence : |
MKAPAVLAPGILVLLFTLVQRSNGE CKEALAKSEMNVNMKYQLPNFTAET PIQNVILHEHHIFLGATNYIYVLNE EDLQKVAEYKTGPVLEHPDCFPCQD CSSKANLSGGVWKDNINMALVVDTY YDDQLISCGSVNRGTCQRHVFPHNH TADIQSEVHCIFSPQIEEPSQCPDC VVSALGAKVLSSVKDRFINFFVGNT INSSYFPDHPLHSISVRRLKETKDG FMFLTDQSYIDVLPEFRDSYPIKYV HAFESNNFIYFLTVQRETLDAQTFH TRIIRFCSINSGLHSYMEMPLECIL TEKRKKRSTKKEVFNILQAAYVSKP GAQLARQIGASLNDDILFGVFAQSK PDSAEPMDRSAMCAFPIKYVNDFFN KIVNKNNVRCLQHFYGPNHEHCFNR TLLRNSSGCEARRDEYRTEFTTALQ RVDLFMGQFSEVLLTSISTFIKGDL TIANLGTSEGRFMQVVVSRSGPSTP HVNFLLDSHPVSPEVIVEHTLNQNG YTLVITGKKITKIPLNGLGCRHFQS CSQCLSAPPFVQCGWCHDKCVRSEE CLSGTWTQQICLPAIYKVFPNSAPL EGGTRLTICGWDFGFRRNNKFDLKK TRVLLGNESCTLTLSESTMNTLKCT VGPAMNKHFNMSIIISNGHGTTQYS TFSYVDPVITSISPKYGPMAGGTLL TLTGNYLNSGNSRHISIGGKTCTLK SVSNSILECYTPAQTISTEFAVKLK IDLANRETSIFSYREDPIVYEIHPT KSFISGGSTITGVGKNLNSVSVPRM VINVHEAGRNFTVACQHRSNSEIIC CTTPSLQQLNLQLPLKTKAFFMLDG ILSKYFDLIYVHNPVFKPFEKPVMI SMGNENVLEIKGNDIDPEAVKGEVL KVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIV QPDQNFTGLIAGVVSISTALLLLLG FFLWLKKRKQIKDLGSELVRYDARV HTPHLDRLVSARSVSPTTEMVSNES VDYRATFPEDQFPNSSQNGSCRQVQ YPLTDMSPILTSGDSDISSPLLQNT VHIDLSALNPELVQAVQHVVIGPSS LIVHFNEVIGRGHFGCVYHGTLLDN DGKKIHCAVKSLNRITDIGEVSQFL TEGIIMKDFSHPNVLSLLGICLRSE GSPLVVLPYMKHGDLRNFIRNETHN PTVKDLIGFGLQVAKGMKYLASKKF VHRDLAARNCMLDEKFTVKVADFGL ARDMYDKEYYSVHNKTGAKLPVKWM ALESLQTQKFTTKSDVWSFGVLLWE LMTRGAPPYPDVNTFDITVYLLQGR RLLQPEYCPDPLYEVMLKCWHPKAE MRPSFSELVSRISAIFSTFIGEHYV HVNATYVNVKCVAPYPSLLSSEDNA DDEVDTRPASFWETS |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
