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Recombinant Human METTL16 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | METTL16-2609H |
| Product Overview : | METT10D MS Standard C13 and N15-labeled recombinant protein (NP_076991) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, leading to intron retention and preventing MAT2A mRNA splicing. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, leading to stimulate splicing of the MAT2A retained intron, and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs. Specifically binds the 3'-end of the MALAT1 long non-coding RNA. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 63.6 kDa |
| AA Sequence : | MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLENC QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN RDLMNQLCTY IRNQIFRLVA VNTRTRPLEQ KLISEEDLAA NDILDYKDDD DKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | METTL16 methyltransferase like 16 [ Homo sapiens (human) ] |
| Official Symbol : | METTL16 |
| Synonyms : | METTL16; methyltransferase like 16; methyltransferase 10 domain containing, METT10D; methyltransferase-like protein 16; MGC3329; putative methyltransferase METT10D; methyltransferase 10 domain containing; methyltransferase 10 domain-containing protein; METT10D; |
| Gene ID : | 79066 |
| mRNA Refseq : | NM_024086 |
| Protein Refseq : | NP_076991 |
| UniProt ID : | Q86W50 |
◆ Recombinant Protein
| METTL16-4409H | Recombinant Human METTL16 Protein, GST-tagged | +Inquiry |
| Mettl16-4042M | Recombinant Mouse Mettl16 Protein, Myc/DDK-tagged | +Inquiry |
| METTL16-13H | Recombinant Human METTL16 Protein, His-tagged | +Inquiry |
| METTL16-9751M | Recombinant Mouse METTL16 Protein | +Inquiry |
| METTL16-687C | Recombinant Cynomolgus METTL16 Protein, His-tagged | +Inquiry |
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◆ Lysates
| METTL16-4361HCL | Recombinant Human METT10D 293 Cell Lysate | +Inquiry |
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METTL1METTL11AMETTL2BMETTL21AMETTL20METTL13METTL5METTL6METTL10METTL7BMETTL16METTL17METTL15METTL11BMETTL21CMETTL2AMETTL4METTL7AMETTL21DMETTL25METTL22METTL23METTL18METTL24METTL14Mettl2METTL21BMETTL19METTL12Mettl3Mettl7a1Mettl7a2Mettl8Mettl9
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