Recombinant Human MINK1 Protein (M1-G314), Tag Free

• Cat.No.: MINK1-1078H
• Product Overview: Recombinant Human MAP4K6(M1-G314) Protein was expressed in Insect cell.

Specification

• Description: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
• Source: Insect cell
• Species: Human
• Tag: No tag
• Form: Liquid
• Protein Length: M1-G314
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: MINK1 misshapen-like kinase 1 [ Homo sapiens (human) ]
• Official Symbol: MINK1
• Synonyms: MINK1; misshapen-like kinase 1; misshapen like kinase 1 (zebrafish); B55; MAP4K6; MINK; misshapen/NIK related kinase; YSK2; ZC3; MEKKK 6; MEK kinase kinase 6; GCK family kinase MINK; misshapen/NIK-related kinase; MAPK/ERK kinase kinase kinase 6; serine/threonine protein kinase; mitogen-activated protein kinase kinase kinase kinase 6; hMINK; hMINKbeta; MGC21111
• Gene ID: 50488
• mRNA Refseq: NM_001024937
• Protein Refseq: NP_001020108
• MIM: 609426
• UniProt ID: Q8N4C8