| Description : |
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
85.3 kDa |
| AA Sequence : |
MGKSESQMDITDINTPKPKKKQRWT PLEISLSVLVLLLTIIAVTMIALYA TYDDGICKSSDCIKSAARLIQNMDA TTEPCTDFFKYACGGWLKRNVIPET SSRYGNFDILRDELEVVLKDVLQEP KTEDIVAVQKAKALYRSCINESAID SRGGEPLLKLLPDIYGWPVATENWE QKYGASWTAEKAIAQLNSKYGKKVL INLFVGTDDKNSVNHVIHIDQPRLG LPSRDYYECTGIYKEACTAYVDFMI SVARLIRQEERLPIDENQLALEMNK VMELEKEIANATAKPEDRNDPMLLY NKMTLAQIQNNFSLEINGKPFSWLN FTNEIMSTVNISITNEEDVVVYAPE YLTKLKPILTKYSARDLQNLMSWRF IMDLVSSLSRTYKESRNAFRKALYG TTSETATWRRCANYVNGNMENAVGR LYVEAAFAGESKHVVEDLIAQIREV FIQTLDDLTWMDAETKKRAEEKALA IKERIGYPDDIVSNDNKLNNEYLEL NYKEDEYFENIIQNLKFSQSKQLKK LREKVDKDEWISGAAVVNAFYSSGR NQIVFPAGILQPPFFSAQQSNSLNY GGIGMVIGHEITHGFDDNGRNFNKD GDLVDWWTQQSASNFKEQSQCMVYQ YGNFSWDLAGGQHLNGINTLGENIA DNGGLGQAYRAYQNYIKKNGEEKLL PGLDLNHKQLFFLNFAQVWCGTYRP EYAVNSIKTDVHSPGNFRIIGTLQN SAEFSEAFHCRKNSYMNPEKKCRVW TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
