| Description : |
This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
98.2 kDa |
| AA Sequence : |
MAGAAAESGRELWTFAGSRDPSAPR LAYGYGPGSLRELRAREFSRLAGTV YLDHAGATLFSQSQLESFTSDLMEN TYGNPHSQNISSKLTHDTVEQVRYR ILAHFHTTAEDYTVIFTAGSTAALK LVAEAFPWVSQGPESSGSRFCYLTD SHTSVVGMRNVTMAINVISIPVRPE DLWSAEERGASASNPDCQLPHLFCY PAQSNFSGVRYPLSWIEEVKSGRLR PVSTPGKWFVLLDAASYVSTSPLDL SAHQADFVPISFYKIFGFPTGLGAL LVHNRAAPLLRKTYFGGGTASAYLA GEDFYIPRQSVAQRFEDGTISFLDV IALKHGFDTLERLTGGMENIKQHTF TLAQYTYMALSSLQYPNGAPVVRIY SDSEFSSPEVQGPIINFNVLDDKGN IIGYSQVDKMASLYNIHLRTGCFCN TGACQRHLGISNEMVRKHFQAGHVC GDNMDLIDGQPTGSVRISFGYMSTL DDVQAFLRFIIDTRLHSSGDWPVPQ AHADTGETGAPSADSQADVIPAVMG RRSLSPQEDALTGSRVWNNSSTVNA VPVAPPVCDVARTQPTPSEKAAGVL EGALGPHVVTNLYLYPIKSCAAFEV TRWPVGNQGLLYDRSWMVVNHNGVC LSQKQEPRLCLIQPFIDLRQRIMVI KAKGMEPIEVPLEENSERTQIRQSR VCADRVSTYDCGEKISSWLSTFFGR PCHLIKQSSNSQRNAKKKHGKDQLP GTMATLSLVNEAQYLLINTSSILEL HRQLNTSDENGKEELFSLKDLSLRF RANIIINGKRAFEEEKWDEISIGSL RFQVLGPCHRCQMICIDQQTGQRNQ HVFQKLSESRETKVNFGMYLMHASL DLSSPCFLSVGSQVLPVLKENVEGH DLPASEKHQDVTSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
