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Recombinant Human MSLN Protein, Fc-tagged, Biotinylated

Cat.No. : MSLN-380H
Product Overview : Biotinylated Recombinant human MSLN protein with Fc tag was expressed in HEK293..
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Description : This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized
Molecular Mass : 59.6 kDa
Protein Length : 630
AA Sequence : MALPTARPLLGSCGTPALGSLLFLL FSLGWVQPSRTLAGETGQEAAPLDG VLANPPNISSLSPRQLLGFPCAEVS GLSTERVRELAVALAQKNVKLSTEQ LRCLAHRLSEPPEDLDALPLDLLLF LNPDAFSGPQACTRFFSRITKANVD LLPRGAPERQRLLPAALACWGVRGS LLSEADVRALGGLACDLPGRFVAES AEVLLPRLVSCPGPLDQDQQEAARA ALQGGGPPYGPPSTWSVSTMDALRG LLPVLGQPIIRSIPQGIVAAWRQRS SRDPSWRQPERTILRPRFRREVEKT ACPSGKKAREIDESLIFYKKWELEA CVDAALLATQMDRVNAIPFTYEQLD VLKHKLDELYPQGYPESVIQHLGYL FLKMSPEDIRKWNVTSLETLKALLE VNKGHEMSPQAPRRPLPQVATLIDR FVKGRGQLDKDTLDTLTAFYPGYLC SLSPEELSSVPPSSIWAVRPQDLDT CDPRQLDVLYPKARLAFQNMNGSEY FVKIQSFLGGAPTEDLKALSQQNVS MDLATFMKLRTDAVLPLTVAEVQKL LGPHVEGLKAEERHRPVRDWILRQR QDDLDTLGLGLQGGIPNGYLVLDLS MQEALSGTPCLLGPGPVLTVLALLL ASTLA
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : MSLN mesothelin [ Homo sapiens (human) ]
Official Symbol : MSLN
Synonyms : MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP;
Gene ID : 10232
mRNA Refseq : NM_001177355
Protein Refseq : NP_001170826
MIM : 601051
UniProt ID : Q13421

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of MSLN in normal tissues? 12/07/2022

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells? 03/19/2022

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed? 03/28/2021

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment? 02/25/2020

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings? 10/07/2019

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients? 11/23/2018

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis? 11/07/2018

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.

Customer Reviews (3)

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Reviews
05/22/2022

    Very satisfied, great product.

    03/06/2022

      Product is high-quality.

      09/30/2021

        Excellent for experiments, reliable.

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