Recombinant Human MSLN Protein, GST-tagged

• Cat.No.: MSLN-5659H
• Product Overview: Human MSLN full-length ORF ( AAH03512.1, 1 a.a. - 621 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 94.3 kDa
• AA Sequence: MALPTARPLLGSCGTPALGSLLFLL FSLGWVQPSRTLAGETGQAAPLDGV LANPPNISSLSPRQLLGFPCAEVSG LSTERVRELAVALAQKNVKLSTEQL RCLAHRLSEPPEDLDALPLDLLLFL NPDAFSGPQACTRFFSRITKANVDL LPRGAPERQRLLPAALACWGVRGSL LSEADVRALGGLACDLPGRFVAESA EVLLPRLVSCPGPLDQDQQEAARAA LQGGGPPYGPPSTWSVSTMDALRGL LPVLGQPIIRSIPQGIVAAWRQRSS RDPSWRQPERTILRPRFRREVEKTA CPSGKKAREIDESLIFYKKWELEAC VDAALLATQMDRVNAIPFTYEQLDV LKHKLDELYPQGYPESVIQHLGYLF LKMSPEDIRKWNVTSLETLKALLEV NKGHEMSPQVATLIDRFVKGRGQLD KDTLDTLTAFYPGYLCSLSPEELSS VPPSSIWAVRPQDLDTCDPRQLDVL YPKARLAFQNMNGSEYFVKIQSFLG GAPTEDLKALSQQNVSMDLATFMKL RTDAVLPLTVAEVQKLLGPHVEGLK AEERHRPVRDWILRQRQDDLDTLGL GLQGGIPNGYLVLDLSVQEALSGTP CLLGPGPVLTVLALLLASTLA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MSLN mesothelin [ Homo sapiens ]
• Official Symbol: MSLN
• Synonyms: MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP
• Gene ID: 10232
• mRNA Refseq: NM_001177355
• Protein Refseq: NP_001170826
• MIM: 601051
• UniProt ID: Q13421