| Description : |
This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
75.8 kDa |
| AA Sequence : |
MEHIRTPKVENVRLVDRVSPKKAAL GTLYLTATHVIFVENSPDARKETWI LHSQISTIEKQATTATGCPLLIRCK NFQIIQLIIPQERDCHDVYISLIRL ARPVKYEELYCFSFNPMLDKEEREQ GWVLIDLSEEYTRMGLPNHYWQLSD VNRDYRVCDSYPTELYVPKSATAHI IVGSSKFRSRRRFPVLSYYYKDNHA SICRSSQPLSGFSARCLEDEQMLQA IRKANPGSDFVYVVDTRPKLNAMAN RAAGKGYENEDNYSNIKFQFIGIEN IHVMRNSLQKMLEVCELKSPSMSDF LWGLENSGWLRHIKAIMDAGIFIAK AVSEEGASVLVHCSDGWDRTAQVCS VASLLLDPHYRTLKGFMVLIEKDWI SFGHKFNHRYGNLDGDPKEISPVID QFIECVWQLMEQFPCAFEFNERFLI HIQHHIYSCQFGNFLCNSQKERREL KIQERTYSLWAHLWKNRADYLNPLF RADHSQTQGTLHLPTTPCNFMYKFW SGMYNRFEKGMQPRQSVTDYLMAVK EETQQLEEELEALEERLEKIQKVQL NCTKVKSKQSEPSKHSGFSTSDNSI ANTPQDYSGNMKSFPSRSPSQGDED SALILTQDNLKSSDPDLSANSDQES GVEDLSCRSPSGGEHAPSEDSGKDR DSDEAVFLTATRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
