Recombinant Human MYO15A Protein, GST-tagged

• Cat.No.: MYO15A-5829H
• Product Overview: Human MYO15A partial ORF ( NP_057323.2, 3432 a.a. - 3530 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 36.63 kDa
• AA Sequence: PCILAINHNGLNFLSTETHELMVKF PLKEIQSTRTQRPTANSSYPYVEIA LGDVAAQRTLQLQLEQGLELCRVVA VHVENLLSAHEKRLTLPPSEITLL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MYO15A myosin XVA [ Homo sapiens (human) ]
• Official Symbol: MYO15A
• Synonyms: MYO15A; myosin XVA; DFNB3; MYO15; unconventional myosin-XV; myosin-XV; unconventional myosin-15
• Gene ID: 51168
• mRNA Refseq: NM_016239
• Protein Refseq: NP_057323
• MIM: 602666
• UniProt ID: Q9UKN7