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Recombinant Human NBN Protein, His-tagged
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| Cat.No. : | NBN-001H |
| Product Overview : | Purified recombinant protein of Human nibrin (NBN), Pro461-Arg754, with N-terminal His tag, expressed in E. coli. |
| Description : | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Molecular Mass : | 34 kDa |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade. |
| Concentration : | >50 μg/mL as determined by microplate BCA method |
| Storage Buffer : | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl. |
| Figure : |
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| Gene Name : | NBN nibrin [ Homo sapiens (human) ] |
| Official Symbol : | NBN |
| Synonyms : | NBN; nibrin; ATV; NBS; P95; NBS1; AT-V1; AT-V2; nibrin; Nijmegen breakage syndrome 1 (nibrin); cell cycle regulatory protein p95; p95 protein of the MRE11/RAD50 complex |
| Gene ID : | 4683 |
| mRNA Refseq : | NM_002485 |
| Protein Refseq : | NP_002476 |
| MIM : | 602667 |
| UniProt ID : | O60934 |
◆ Recombinant Protein
| NBN-01H | Recombinant Human NBN Protein, His-tagged | +Inquiry |
| NBN-2289Z | Recombinant Zebrafish NBN | +Inquiry |
| NBN-3912R | Recombinant Rat NBN Protein | +Inquiry |
| NBN-5909C | Recombinant Chicken NBN | +Inquiry |
| NBN-2951R | Recombinant Rhesus monkey NBN Protein, His-tagged | +Inquiry |
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◆ Lysates
| NBN-3957HCL | Recombinant Human NBN 293 Cell Lysate | +Inquiry |
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