Recombinant Human NBN Protein, His-tagged


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Recombinant Human NBN Protein, His-tagged

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Cat.No. : NBN-001H
Product Overview : Purified recombinant protein of Human nibrin (NBN), Pro461-Arg754, with N-terminal His tag, expressed in E. coli.
Description : Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 34 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
Figure :

Gene Name : NBN nibrin [ Homo sapiens (human) ]
Official Symbol : NBN
Synonyms : NBN; nibrin; ATV; NBS; P95; NBS1; AT-V1; AT-V2; nibrin; Nijmegen breakage syndrome 1 (nibrin); cell cycle regulatory protein p95; p95 protein of the MRE11/RAD50 complex
Gene ID : 4683
mRNA Refseq : NM_002485
Protein Refseq : NP_002476
MIM : 602667
UniProt ID : O60934
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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