Recombinant Human NBN Protein, His-tagged NBN-001H

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Recombinant Human NBN Protein, His-tagged

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Cat.No. :	NBN-001H
Product Overview :	Purified recombinant protein of Human nibrin (NBN), Pro461-Arg754, with N-terminal His tag, expressed in E. coli.
Description :	Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Source :	E. coli
Species :	Human
Tag :	His
Molecular Mass :	34 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Stability :	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage :	Store at -80 centigrade.
Concentration :	>50 μg/mL as determined by microplate BCA method
Storage Buffer :	25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
Figure :

Gene Name :	NBN nibrin [ Homo sapiens (human) ]
Official Symbol :	NBN
Synonyms :	NBN; nibrin; ATV; NBS; P95; NBS1; AT-V1; AT-V2; nibrin; Nijmegen breakage syndrome 1 (nibrin); cell cycle regulatory protein p95; p95 protein of the MRE11/RAD50 complex
Gene ID :	4683
mRNA Refseq :	NM_002485
Protein Refseq :	NP_002476
MIM :	602667
UniProt ID :	O60934