| Description : |
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains. NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma. CD56 is commonly used along with CD3 and CD16 to identify human NK cells (Mouse NK cells do not express CD56). Human natural killer cells are CD3-CD56+. The large subset with high CD16 expression are mature cytotoxic natural killer cells, while those with low CD16 expression are immature precursors and cytokine producers. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His |
| Molecular Mass : |
~93 kDa |
| AA Sequence : |
LQVDIVPSQGEISVGESKFFLCQVA GDAKDKDISWFSPNGEKLTPNQQRI SVVWNDDSSSTLTIYNANIDDAGIY KCVVTGEDGSESEATVNVKIFQKLM FKNAPTPQEFREGEDAVIVCDVVSS LPPTIIWKHKGRDVILKKDVRFIVL SNNYLQIRGIKKTDEGTYRCEGRIL ARGEINFKDIQVIVNVPPTIQARQN IVNATANLGQSVTLVCDAEGFPEPT MSWTKDGEQIEQEEDDEKYIFSDDS SQLTIKKVDKNDEAEYICIAENKAG EQDATIHLKVFAKPKITYVENQTAM ELEEQVTLTCEASGDPIPSITWRTS TRNISSEEKASWTRPEKQETLDGHM VVRSHARVSSLTLKSIQYTDAGEYI CTASNTIGQDSQSMYLEVQYAPKLQ GPVAVYTWEGNQVNITCEVFAYPSA TISWFRDGQLLPSSNYSNIKIYNTP SASYLEVTPDSENDFGNYNCTAVNR IGQESLEFILVQADTPSSPSIDQVE PYSSTAQVQFDEPEATGGVPILKYK AEWRAVGEEVWHSKWYDAKEASMEG IVTIVGLKPETTYAVRLAALNGKGL GEISAASEFKTQPVQGEPSAPKLEG QMGEDGNSIKVNLIKQDDGGSPIRH YLVRYRALSSEWKPEIRLPSGSDHV MLKSLDWNAEYEVYVVAENQQGKSK AAHFVFRTSAQPTAIPANGSPTSG |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
