Recombinant Human NCR3 protein, His-tagged
Cat.No. : | NCR3-785H |
Product Overview : | Recombinant Human NCR3 (Asp25-Ser262) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Asp25 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 28.6 kDa. The protein migrates as 38-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Asp25-Ser262 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | NCR3 |
Official Symbol : | NCR3 |
Synonyms : | 1C7; MALS; CD337; LY117; NKp30 |
Gene ID : | 259197 |
mRNA Refseq : | NM_147130.3 |
Protein Refseq : | NP_667341.1 |
MIM : | 611550 |
UniProt ID : | O14931 |
Products Types
◆ Recombinant Protein | ||
NCR3-498C | Active Recombinant Cynomolgus NCR3 Protein, His-tagged | +Inquiry |
NCR3-2780R | Recombinant Rhesus Macaque NCR3 Protein, His (Fc)-Avi-tagged | +Inquiry |
NCR3-399H | Recombinant Human NCR3 Protein, Fc-tagged | +Inquiry |
NCR3-256H | Recombinant Human NCR3 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
NCR3-398H | Recombinant Human NCR3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NCR3-2652HCL | Recombinant Human NCR3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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