Recombinant Human NCR3 protein, His-tagged

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Recombinant Human NCR3 protein, His-tagged

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Cat.No. : NCR3-785H
Product Overview : Recombinant Human NCR3 (Asp25-Ser262) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
Description : The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome.
Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Asp25
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 28.6 kDa. The protein migrates as 38-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Asp25-Ser262
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name : NCR3
Official Symbol : NCR3
Synonyms : 1C7; MALS; CD337; LY117; NKp30
Gene ID : 259197
mRNA Refseq : NM_147130.3
Protein Refseq : NP_667341.1
MIM : 611550
UniProt ID : O14931

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