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Recombinant Human NCR3LG1 protein, Avi & His-tagged, Biotinylated

Cat.No. : NCR3LG1-1290H
Product Overview : Biotinylated Human B7-H6, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Ser 262 (Accession # Q68D85-1). Biotinylation of this product is performed using Avitag technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin. The biotin to protein ratio is 0.5-1 as determined by the HABA assay.
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Description : The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Source : HEK293
Species : Human
Tag : Avi & His
Predicted N Terminal : Asp 25
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 30.4 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Asp 25 - Ser 262
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 [ Homo sapiens (human) ]
Official Symbol : NCR3LG1
Synonyms : B7H6; B7-H6; DKFZp686O24166; B7 homolog 6; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167; natural cytotoxicity triggering receptor 3 ligand 1
Gene ID : 374383
mRNA Refseq : NM_001202439.2
Protein Refseq : NP_001189368.1
UniProt ID : Q68D85

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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