Recombinant Human NEU1 protein, His-tagged
Cat.No. : | NEU1-580H |
- Specification
- Gene Information
- Related Products
Product overview : | Recombinant Human NEU1 (Q99519) aa. (Ala47~Leu415) fused with His tag was produced in E. coli cells. |
Description : | The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 45kDa; Accurate Molecular Mass: 46kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Ala47~Leu415 |
Purity : | >98% |
Characteristic : | Isoelectric point is 5.3. |
Applications : | Cell culture; Activity Assays; In vivo assays. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | 20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex |
Gene Name : | NEU1 neuraminidase 1 [ Homo sapiens (human) ] |
Official Symbol : | NEU1 |
Synonyms : | NEU1; neuraminidase 1; NEU; NANH; SIAL1; sialidase-1; G9 sialidase; N-acetyl-alpha-neuraminidase 1; acetylneuraminyl hydrolase; exo-alpha-sialidase; lysosomal sialidase; sialidase 1 (lysosomal sialidase) |
Gene ID : | 4758 |
mRNA Refseq : | NM_000434.3 |
Protein Refseq : | NP_000425.1 |
UniProt ID : | Q99519 |
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◆ Lysates | ||
NEU1-3871HCL | Recombinant Human NEU1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there is ongoing research aimed at understanding the molecular mechanisms of NEU1 and developing potential therapeutic interventions for associated disorders.
NEU1 deficiency can lead to a group of rare genetic disorders known as sialidosis, which can cause a range of symptoms including intellectual disabilities, muscle weakness, and skeletal abnormalities.
NEU1 protein has also been implicated in certain types of cancer and neurodegenerative diseases.
Yes, NEU1 deficiency can lead to additional complications such as hepatosplenomegaly (enlargement of the liver and spleen), seizures, and difficulty swallowing.
Currently, there are no specific cures for NEU1 deficiency or sialidosis. Treatment is generally supportive and aims to manage the symptoms.
Customer Reviews (3)
Write a reviewIts purity and reliability ensure reliable and reproducible results in a variety of research applications.
The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.
The NEU1 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).
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