Recombinant Human NFATC1, GST-tagged

• Cat.No.: NFATC-1474H
• Product Overview: Recombinant full-length human NFATC1 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 125 kDa.

Specification

• Cat. No.: NFATC-1474H
• Description: NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development. NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [ Homo sapiens ]
• Synonyms: NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; NFAT2; NFATc; NF-ATC; MGC138448; NFAT transcription complex cytosolic component; Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NFATC; NFAT transcription complex cytosolic component
• Gene ID: 4772
• mRNA Refseq: NM_006162
• Protein Refseq: NP_006153
• MIM: 600489
• UniProt ID: O95644
• Chromosome Location: 18q23
• Pathway: Axon guidance; B cell receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; VEGF signaling pathway; Wnt signaling pathway
• Function: FK506 binding; promoter binding; protein binding; transcription activator activity; transcription factor activity