Description : |
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
166.7 kDa |
AA Sequence : |
MATARTFGPEREAEPAKEARVVGSE LVDTYTVYIIQVTDGSHEWTVKHRY SDFHDLHEKLVAERKIDKNLLPPKK IIGKNSRSLVEKREKDLEVYLQKLL AAFPGVTPRVLAHFLHFHFYEINGI TAALAEELFEKGEQLLGAGEVFAIG PLQLYAVTEQLQQGKPTCASGDAKT DLGHILDFTCRLKYLKVSGTEGPFG TSNIQEQLLPFDLSIFKSLHQVEIS HCDAKHIRGLVASKPTLATLSVRFS ATSMKEVLVPEASEFDEWEPEGTTL EGPVTAVIPTWQALTTLDLSHNSIS EIDESVKLIPKIEFLDLSHNGLLVV DNLQHLYNLVHLDLSYNKLSSLEGL HTKLGNIKTLNLAGNLLESLSGLHK LYSLVNLDLRDNRIEQMEEVRSIGS LPCLEHVSLLNNPLSIIPDYRTKVL AQFGERASEVCLDDTVTTEKELDTV EVLKAIQKAKEVKSKLSNPEKKGGE DSRLSAAPCIRPSSSPPTVAPASAS LPQPILSNQGIMFVQEEALASSLSS TDSLTPEHQPIAQGCSDSLESIPAG QAASDDLRDVPGAVGGASPEHAEPE VQVVPGSGQIIFLPFTCIGYTATNQ DFIQRLSTLIRQAIERQLPAWIEAA NQREEGQGEQGEEEDEEEEEEEDVA ENRYFEMGPPDVEEEEGGGQGEEEE EEEEDEEAEEERLALEWALGADEDF LLEHIRILKVLWCFLIHVQGSIRQF AACLVLTDFGIAVFEIPHQESRGSS QHILSSLRFVFCFPHGDLTEFGFLM PELCLVLKVRHSENTLFIISDAANL HEFHADLRSCFAPQHMAMLCSPILY GSHTSLQEFLRQLLTFYKVAGGCQE RSQGCFPVYLVYSDKRMVQTAAGDY SGNIEWASCTLCSAVRRSCCAPSEA VKSAAIPYWLLLTPQHLNVIKADFN PMPNRGTHNCRNRNSFKLSRVPLST VLLDPTRSCTQPRGAFADGHVLELL VGYRFVTAIFVLPHEKFHFLRVYNQ LRASLQDLKTVVIAKTPGTGGSPQG SFADGQPAERRASNDQRPQEVPAEA LAPAPVEVPAPAPAAASASGPAKTP APAEASTSALVPEETPVEAPAPPPA EAPAQYPSEHLIQATSEENQIPPHL PACPSLRHVASLRGSAIIELFHSSI AEVENEELRHLMWSSVVFYQTPGLE VTACVLLSTKAVYFVLHDGLRRYFS EPLQDFWHQKNTDYNNSPFHISQCF VLKLSDLQSVNVGLFDQHFRLTGST PMQVVTCLTRDSYLTHCFLQHLMVV LSSLERTPSPEPVDKDFYSEFGNKT TGKMENYELIHSSRVKFTYPSEEEI GDLTFTVAQKMAEPEKAPALSILLY VQAFQVGMPPPGCCRGPLRPKTLLL TSSEIFLLDEDCVHYPLPEFAKEPP QRDRYRLDDGRRVRDLDRVLMGYQT YPQALTLVFDDVQGHDLMGSVTLDH FGEVPGGPARASQGREVQWQVFVPS AESREKLISLLARQWEALCGRELPV ELTGTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |