Recombinant Human NLRP11 Protein, GST-tagged

• Cat.No.: NLRP11-5919H
• Product Overview: Human NLRP11 full-length ORF ( NP_659444.1, 1 a.a. - 1033 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 144.2 kDa
• AA Sequence: MAESDSTDFDLLWYLENLSDKEFQS FKKYLARKILDFKLPQFPLIQMTKE ELANVLPISYEGQYIWNMLFSIFSM MRKEDLCRKIIGRRNRNQEACKAVM RRKFMLQWESHTFGKFHYKFFRDVS SDVFYILQLAYDSTSYYSANNLNVF LMGERASGKTIVINLAVLRWIKGEM WQNMISYVVHLTSHEINQMTNSSLA ELIAKDWPDGQAPIADILSDPKKLL FILEDLDNIRFELNVNESALCSNST QKVPIPVLLVSLLKRKMAPGCWFLI SSRPTRGNNVKTFLKEVDCCTTLQL SNGKREIYFNSFFKDRQRASAALQL VHEDEILVGLCRVAILCWITCTVLK RQMDKGRDFQLCCQTPTDLHAHFLA DALTSEAGLTANQYHLGLLKRLCLL AAGGLFLSTLNFSGEDLRCVGFTEA DVSVLQAANILLPSNTHKDRYKFIH LNVQEFCTAIAFLMAVPNYLIPSGS REYKEKREQYSDFNQVFTFIFGLLN ANRRKILETSFGYQLPMVDSFKWYS VGYMKHLDRDPEKLTHHMPLFYCLY ENREEEFVKTIVDALMEVTVYLQSD KDMMVSLYCLDYCCHLRTLKLSVQR IFQNKEPLIRPTASQMKSLVYWREI CSLFYTMESLRELHIFDNDLNGISE RILSKALEHSSCKLRTLKLSYVSTA SGFEDLLKALARNRSLTYLSINCTS ISLNMFSLLHDILHEPTCQISHLSL MKCDLRASECEEIASLLISGGSLRK LTLSSNPLRSDGMNILCDALLHPNC TLISLVLVFCCLTENCCSALGRVLL FSPTLRQLDLCVNRLKNYGVLHVTF PLLFPTCQLEELHLSGCFFSSDICQ YIAIVIATNEKLRSLEIGSNKIEDA GMQLLCGGLRHPNCMLVNIGLEECM LTSACCRSLASVLTTNKTLERLNLL QNHLGNDGVAKLLESLISPDCVLKV VGLPLTGLNTQTQQLLMTVKERKPS LIFLSETWSLKEGREIGVTPASQPG SIIPNSNLDYMFFKFPRMSAAMRTS NTASRQPL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NLRP11 NLR family, pyrin domain containing 11 [ Homo sapiens ]
• Official Symbol: NLRP11
• Synonyms: NLRP11; NLR family, pyrin domain containing 11; NACHT, leucine rich repeat and PYD containing 11 , NALP11; NACHT, LRR and PYD domains-containing protein 11; CLR19.6; NOD17; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 11; PAN10; PYPAF6; PAAD- and NACHT-containing protein 10; PYRIN-containing APAF1-like protein 6; PAAD- and NACHT-containing protein 10B; NACHT, LRR and PYD containing protein 11; PAAD-and NACHT domain-containing protein 10; NACHT, leucine rich repeat and PYD containing 11; nucleotide-binding oligomerization domain protein 17; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11; NALP11; PYPAF7; FLJ26273
• Gene ID: 204801
• mRNA Refseq: NM_145007
• Protein Refseq: NP_659444
• MIM: 609664
• UniProt ID: P59045