Recombinant Human NLRP13 Protein, GST-tagged

• Cat.No.: NLRP13-5920H
• Product Overview: Human NLRP13 full-length ORF ( AAI48743.1, 1 a.a. - 1043 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 141.68 kDa
• AA Sequence: MNFSVITCPNGGTNQGLLPYLMALD QYQLEEFKLCLEPQQLMDFWSAPQG HFPRIPWANLRAADPLNLSFLLDEH FPKGQAWKVVLGIFQTMNLTSLCEK VRAEMKENVQTQELQDPTQEDLEML EAAAGNMQTQGCQDPNQEELDELEE ETGNVQAQGCQDPNQEEPEMLEEAD HRRKYRENMKAELLETWDNISWPKD HVYIRNTSKDEHEELQRLLDPNRTR AQAQTIVLVGRAGVGKTTLAMQAML HWANGVLFQQRFSYVFYLSCHKIRY MKETTFAELISLDWPDFDAPIEEFM SQPEKLLFIIDGFEEIIISESRSES LDDGSPCTDWYQELPVTKILHSLLK KELVPLATLLITIKTWFVRDLKASL VNPCFVQITGFTGDDLRVYFMRHFD DSSEVEKILQQLRKNETLFHSCSAP MVCWTVCSCLKQPKVRYYDLQSITQ TTTSLYAYFFSNLFSTAEVDLADDS WPGQWRALCSLAIEGLWSMNFTFNK EDTEIEGLEVPFIDSLYEFNILQKI NDCGGCTTFTHLSFQEFFAAMSFVL EEPREFPPHSTKPQEMKMLLQHVLL DKEAYWTPVVLFFFGLLNKNIAREL EDTLHCKISPRVMEELLKWGEELGK AESASLQFHILRLFHCLHESQEEDF TKKMLGRIFEVDLNILEDEELQASS FCLKHCKRLNKLRLSVSSHILERDL EILETSKFDSRMHAWNSICSTLVTN ENLHELDLSNSKLHASSVKGLCLAL KNPRCKVQKLTCKSVTPEWVLQDLI IALQGNSKLTHLNFSSNKLGMTVPL ILKALRHSACNLKYLCLEKCNLSAA SCQDLALFLTSIQHVTRLCLGFNRL QDDGIKLLCAALTHPKCALERLELW FCQLAAPACKHLSDALLQNRSLTHL NLSKNSLRDEGVKFLCEALGRPDGN LQSLNLSGCSFTREGCGELANALSH NHNVKILDLGENDLQDDGVKLLCEA LKPHRALHTLGLAKCNLTTACCQHL FSVLSSSKSLVNLNLLGNELDTDGV KMLCKALKKSTCRLQKLG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NLRP13 NLR family, pyrin domain containing 13 [ Homo sapiens ]
• Official Symbol: NLRP13
• Synonyms: NLRP13; NLR family, pyrin domain containing 13; NACHT, leucine rich repeat and PYD containing 13 , NALP13; NACHT, LRR and PYD domains-containing protein 13; CLR19.7; NOD14; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 13; PAN13; NACHT, LRR and PYD containing protein 13; NACHT, leucine rich repeat and PYD containing 13; nucleotide-binding oligomerization domain protein 14; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13; NALP13
• Gene ID: 126204
• mRNA Refseq: NM_176810
• Protein Refseq: NP_789780
• MIM: 609660
• UniProt ID: Q86W25