Recombinant Human NR2F6 Protein (1-404 aa), His-SUMO-tagged

• Cat.No.: NR2F6-1959H
• Product Overview: Recombinant Human NR2F6 Protein (1-404 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length.

Specification

• Description: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 59.0 kDa
• Protein length: 1-404 aa
• AA Sequence: MAMVTGGWGGPGGDTNGVDKAGGYP RAAEDDSASPPGAASDAEPGDEERP GLQVDCVVCGDKSSGKHYGVFTCEG CKSFFKRSIRRNLSYTCRSNRDCQI DQHHRNQCQYCRLKKCFRVGMRKEA VQRGRIPHSLPGAVAASSGSPPGSA LAAVASGGDLFPGQPVSELIAQLLR AEPYPAAAGRFGAGGGAAGAVLGID NVCELAARLLFSTVEWARHAPFFPE LPVADQVALLRLSWSELFVLNAAQA ALPLHTAPLLAAAGLHAAPMAAERA VAFMDQVRAFQEQVDKLGRLQVDSA EYGCLKAIALFTPDACGLSDPAHVE SLQEKAQVALTEYVRAQYPSQPQRF GRLLLRLPALRAVPASLISQLFFMR LVGKTPIETLIRDMLLSGSTFNWPY GSGQ
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: NR2F6 nuclear receptor subfamily 2, group F, member 6 [ Homo sapiens ]
• Official Symbol: NR2F6
• Synonyms: NR2F6; ERBAL2; EAR 2; ERBA-related gene-2; EAR2; EAR-2
• Gene ID: 2063
• mRNA Refseq: NM_005234
• Protein Refseq: NP_005225
• MIM: 132880
• UniProt ID: P10588