| Description : |
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
104.4 kDa |
| AA Sequence : |
MAFIRKKQQEQQLQLYSKERFSLLL LNLEEYYFEQHRANHILHKGSHHER KIRGSLKICSKSVIFEPDSISQPII KIPLRDCIKIGKHGENGANRHFTKA KSGGISLIFSQVYFIKEHNVVAPYK IERGKMEYVFELDVPGKVEDVVETL LQLHRASCLDKLGDQTAMITAILQS RLARTSFDKNRFQNISEKLHMECKA EMVTPLVTNPGHVCITDTNLYFQPL NGYPKPVVQITLQDVRRIYKRRHGL MPLGLEVFCTEDDLCSDIYLKFYEP QDRDDLYFYIATYLEHHVAEHTAES YMLQWQRGHLSNYQYLLHLNNLADR SCNDLSQYPVFPWIIHDYSSSELDL SNPGTFRDLSKPVGALNKERLERLL TRYQEMPEPKFMYGSHYSSPGYVLF YLVRIAPEYMLCLQNGRFDNADRMF NSIAETWKNCLDGATDFKELIPEFY GDDVSFLVNSLKLDLGKRQGGQMVD DVELPPWASSPEDFLQKSKDALESN YVSEHLHEWIDLIFGYKQKGSDAVG AHNVFHPLTYEGGVDLNSIQDPDEK VAMLTQILEFGQTPKQLFVTPHPRR ITPKFKSLSQTSSYNASMADSPGEE SFEDLTEESKTLAWNNITKLQLHEH YKIHKEAVTGITVSRNGSSVFTTSQ DSTLKMFSKESKMLQRSISFSNMAL SSCLLLPGDATVITSSWDNNVYFYS IAFGRRQDTLMGHDDAVSKICWHDN RLYSASWDSTVKVWSGVPAEMPGTK RHHFDLLAELEHDVSVDTISLNAAS TLLVSGTKEGTVNIWDLTTATLMHQ IPCHSGIVCDTAFSPDSRHVLSTGT DGCLNVIDVQTGMLISSMTSDEPQR CFVWDGNSVLSGSQSGELLVWDLLG AKISERIQGHTGAVTCIWMNEQCSS IITGGEDRQIIFWKLQYTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
