"NTHL1" Related Products


Recombinant Human NTHL1 protein, MYC/DDK-tagged

Cat.No.: NTHL1-20H
Product Overview: Recombinant Human NTHL1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description: The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.
Source: HEK293
Species: Human
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 34.2 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: NTHL1 nth endonuclease III-like 1 (E. coli) [ Homo sapiens ]
Official Symbol: NTHL1
Synonyms: NTHL1; nth endonuclease III-like 1 (E. coli); nth (E.coli endonuclease III) like 1; endonuclease III-like protein 1; NTH1; OCTS3;
Gene ID: 4913
mRNA Refseq: NM_002528
Protein Refseq: NP_002519
MIM: 602656
UniProt ID: P78549
Chromosome Location: 16p13.3
Pathway: Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged pyrimidine, organism-specific biosystem; DNA Repair, organism-specific biosystem;
Function: 4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; endonuclease activity; hydrolase activity, acting on glycosyl bonds; lyase activity; metal ion binding; protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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