Recombinant Human NUP98 protein, hFC-tagged NUP98-5793H

Recombinant Human NUP98 protein, hFC-tagged

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Recombinant Human NUP98 protein, hFC-tagged

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Cat.No. : NUP98-5793H
Product Overview : Recombinant Human NUP98 protein(NP_005378.4)(1-880 aa) was fused to hFC-tagged at C-terminus and expressed in HEK293.
Description : Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin.
Source : HEK293
Species : Human
Tag : hFC
Form : If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Molecular Mass : 116 kDa
Protein length : Partial
AA Sequence : MFNKSFGTPFGGGTG GFGTTSTFGQNTGFG TTSGGAFGTSAFGSS NNTGGLFGNSQTKPG GLFGTSSFSQPATST STGFGFGTSTGTANT LFGTASTGTSLFSSQ NNAFAQNKPTGFGNF GTSTSSGGLFGTTNT TSNPFGSTSGSLFGP SSFTAAPTGTTIKFN PPTGTDTMVKAGVST NISTKHQCITAMKEY ESKSLEELRLEDYQA NRKGPQNQVGAGTTT GLFGSSPATSSATGL FSSSTTNSGFAYGQN KTAFGTSTTGFGTNP GGLFGQQNQQTTSLF SKPFGQATTTQNTGF SFGNTSTIGQPSTNT MGLFGVTQASQPGGL FGTATNTSTGTAFGT GTGLFGQTNTGFGAV GSTLFGNNKLTTFGS STTSAPSFGTTSGGL FGNKPTLTLGTNTNT SNFGFGTNTSGNSIF GSKPAPGTLGTGLGA GFGTALGAGQASLFG NNQPKIGGPLGTGAF GAPGFNTTTATLGFG APQAPVALTDPNASA AQQAVLQQHINSLTY SPFGDSPLFRNPMSD PKKKEERLKPTNPAA QKALTTPTHYKLTPR PATRVRPKALQTTGT AKSHLFDGLDDDEPS LANGAFMPKKSIKKL VLKNLNNSNLFSPVN RDSENLASPSEYPEN GERFSFLSKPVDENH QQDGDEDSLVSHFYT NPIAKPIPQTPESAG NKHSNSNSVDDTIVA LNMRAALRNGLEGSS EETSFHDESLQDDRE EIENNSYHMHPAGII LTKVGYYTIPSMDDL AKITNEKGECIVSDF TIGRKGYGSIYFEGD VNLTNLNLDDIVHIR RKEVVVYLDDNQKPP VGEGLNRKAEVTLDG VWPTDKTSRCLIKSP DRLADINYEGRLEAV SRKQGAQFKEYRPET GSWVFKVSHF
Purity : Greater than 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Storage : Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
SDS-PAGE of NUP98-5793H :

Gene Name : NUP98
Official Symbol : NUP98
Synonyms : 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2 ; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98 Nup96; Nucleoporin 98kD ; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196 ; NUP96; Nup98; Nup98-Nup96; NUP98_HUMAN
Gene ID : 4928
mRNA Refseq : NM_005387.7
Protein Refseq : NP_005378.4
UniProt ID : P52948

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