Recombinant Human OCLN

Cat.No. : OCLN-27768TH
Product Overview : Recombinant fragment corresponding to amino acids 423-522 of Human Occludin with an N terminal proprietary tag; Predicted MWt 36.63 kDa inclusive of tag.
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Description : This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : ITSDQQRQLYKRNFDTGLQEYKSLQ SELDEINKELSRLDKELDDYREESE EYMAAADEYNRLKQVKGSADYKSKK NHCKQLKSKLSHIKKMVGDYDRQKT
Sequence Similarities : Belongs to the ELL/occludin family.Contains 1 MARVEL domain.
Gene Name : OCLN occludin [ Homo sapiens ]
Official Symbol : OCLN
Synonyms : OCLN; occludin; tight junction protein occludin TM4 minus;
Gene ID : 100506658
mRNA Refseq : NM_001205254
Protein Refseq : NP_001192183
MIM : 602876
Uniprot ID : Q16625
Chromosome Location : 5q13.1
Pathway : Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Leukocyte transendothelial migration, organism-specific biosystem;
Function : protein binding; structural molecule activity; thiopurine S-methyltransferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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