Recombinant Human OCLN
Cat.No. : | OCLN-27768TH |
Product Overview : | Recombinant fragment corresponding to amino acids 423-522 of Human Occludin with an N terminal proprietary tag; Predicted MWt 36.63 kDa inclusive of tag. |
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Description : | This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | ITSDQQRQLYKRNFDTGLQEYKSLQ SELDEINKELSRLDKELDDYREESE EYMAAADEYNRLKQVKGSADYKSKK NHCKQLKSKLSHIKKMVGDYDRQKT |
Sequence Similarities : | Belongs to the ELL/occludin family.Contains 1 MARVEL domain. |
Tag : | Non |
Gene Name : | OCLN occludin [ Homo sapiens ] |
Official Symbol : | OCLN |
Synonyms : | OCLN; occludin; tight junction protein occludin TM4 minus; |
Gene ID : | 100506658 |
mRNA Refseq : | NM_001205254 |
Protein Refseq : | NP_001192183 |
MIM : | 602876 |
Uniprot ID : | Q16625 |
Chromosome Location : | 5q13.1 |
Pathway : | Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Leukocyte transendothelial migration, organism-specific biosystem; |
Function : | protein binding; structural molecule activity; thiopurine S-methyltransferase activity; |
Products Types
◆ Recombinant Protein | ||
Ocln-425M | Recombinant Mouse Ocln Protein, His-tagged | +Inquiry |
Ocln-1882M | Recombinant Mouse Ocln Protein, His-tagged | +Inquiry |
Ocln-4569M | Recombinant Mouse Ocln Protein, Myc/DDK-tagged | +Inquiry |
OCLN-3815R | Recombinant Rat OCLN Protein, His (Fc)-Avi-tagged | +Inquiry |
OCLN-2523H | Recombinant Human OCLN Protein, His-tagged | +Inquiry |
◆ Lysates | ||
OCLN-3603HCL | Recombinant Human OCLN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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