Recombinant Human ONECUT1

• Cat.No.: ONECUT1-128H
• Product Overview: Recombinant full-length human HNF6 was expressed in E. coli and refolded to soluble form.

Specification

• Description: HNF6 is a member of the phylogenetically unrelated family of hepatocyte nuclear factors (HNFs) that regulate transcription of various genes, many of which are liver-specific. The HNF6 protein binds to promoters as a monomer, and contains a homeobox domain and a CUT DNA-binding domain. During embryonic development, HNF6 expression plays a key role in hepatic bilary tree development, and is used as a marker for hepatic lineage cells.
• Source: E. coli
• Species: Human
• Form: 201 µg/ml (determined by Bradford assay) in 500 mM L-arginine, 300 mM guanidine-HCl, 50 mM HEPES, 5 mM cystamine, 5 mM cysteamine, 5 mM CaCl2, 3 mM DTT, pH 7.5
• Molecular Mass: 465 residues; 51.0 kDa
• Purity: >90% by SDS-PAGE
• Storage: Store at -80 °C. Avoid multiple freeze-thaws.

Gene Information

• Gene Name: ONECUT1 one cut homeobox 1 [ Homo sapiens ]
• Official Symbol: ONECUT1
• Synonyms: ONECUT1; one cut homeobox 1; HNF6, HNF6A, one cut domain, family member 1; hepatocyte nuclear factor 6; HNF 6; one cut domain family member 1; one cut domain, family member 1; hepatocyte nuclear factor 6, alpha; HNF6; HNF-6; HNF6A
• Gene ID: 3175
• mRNA Refseq: NM_004498
• Protein Refseq: NP_004489
• MIM: 604164
• UniProt ID: Q9UBC0
• Chromosome Location: 15q21.3
• Pathway: Developmental Biology, organism-specific biosystem; FOXM1 transcription factor network, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Regulation of beta-cell development, organism-specific biosystem; Regulation of gene expression in early pancreatic precursor cells, organism-specific biosystem; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, organism-specific biosystem
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity