Recombinant Human OPRM1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: OPRM1-3030H
• Product Overview: OPRM1 MS Standard C13 and N15-labeled recombinant protein (NP_000905) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 44.8 kDa
• AA Sequence: MDSSAAPTNASNCTDALAYSSCSPA PSPGSWVNLSHLDGNLSDPCGPNRT DLGGRDSLCPPTGSPSMITAITIMA LYSIVCVVGLFGNFLVMYVIVRYTK MKTATNIYIFNLALADALATSTLPF QSVNYLMGTWPFGTILCKIVISIDY YNMFTSIFTLCTMSVDRYIAVCHPV KALDFRTPRNAKIINVCNWILSSAI GLPVMFMATTKYRQGSIDCTLTFSH PTWYWENLLKICVFIFAFIMPVLII TVCYGLMILRLKSVRMLSGSKEKDR NLRRITRMVLVVVAVFIVCWTPIHI YVIIKALVTIPETTFQTVSWHFCIA LGYTNSCLNPVLYAFLDENFKRCFR EFCIPTSSNIEQQNSTRIRQNTRDH PSTANTVDRTNHQLENLEAETAPLP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: OPRM1 opioid receptor mu 1 [ Homo sapiens (human) ]
• Official Symbol: OPRM1
• Synonyms: OPRM1; opioid receptor, mu 1; mu-type opioid receptor; MOR1; MOP; hMOP; M-OR-1; mu opiate receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant hMOR-1S; mu opioid receptor splice variant hMOR-1Z; mu opioid receptor splice variant hMOR-1b; mu opioid receptor splice variant hMOR-1Y2; mu opioid receptor splice variant hMOR-1Y3; MOR; LMOR; OPRM; KIAA0403
• Gene ID: 4988
• mRNA Refseq: NM_000914
• Protein Refseq: NP_000905
• MIM: 600018
• UniProt ID: P35372