Recombinant Human OSM protein, His-Avi-tagged

• Cat.No.: OSM-725H
• Product Overview: Recombinant Human Oncostatin M Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Ala26-Arg221.

Specification

• Description: OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDSKS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in 20mM PBS,pH7.4
• Molecular Mass: The protein has a predicted MW of 25.1 KDa. Due to glycosylation, the protein migrates to 30- 40KDa based on Bis-Tris PAGE result.
• Protein length: Ala26-Arg221
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: OSM oncostatin M [ Homo sapiens (human) ]
• Official Symbol: OSM
• Synonyms: OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration .
• Gene ID: 5008
• mRNA Refseq: NM_001319108.2
• Protein Refseq: NP_001306037.1
• MIM: 165095
• UniProt ID: P13725