Recombinant Human PA28B Protein, His-tagged

• Cat.No.: PA28B-306H
• Product Overview: Recombinant Human PA28B Protein is produced by Bacteria expression system. This protein is fused with a His tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PA28 (also called the 11S regulatory complex) is another activator of the 20S proteasome, which assembles on either one or both ends of the 20S proteasome in an ATP-independent manner. PA28 can greatly enhance the peptidase activities of the 20S proteasome, but not for degradation of ubiquitinated proteins. The PA28 activator is a complex of two alternating homologous subunits, PA28α and PA28β, which assembles as a hexameric ring with an α3β3 stoichiometry. PA28α and PA28β are induced by interferon. Functionally, PA28 enhances the generation of class I peptides for antigen presentation. The third subunit, PA28γ, was recently identified in the nucleus. Recombinant PA28α and PA28β form a heptomeric ring; whereas PA28γ forms a hexameric ring. All of them can stimulate the peptidase activities of the 20S proteasome.
• Form: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
• Molecular Mass: 27.4 kDa
• Purity: > 95 % by SDS-PAGE
• Storage: Store at -80 centigrade; avoid multiple freeze-thaw cycles.

Gene Information

• Gene Name: PSME2 proteasome activator subunit 2 ( Homo sapiens (human) )
• Official Symbol: PSME2
• Synonyms: PSME2; REGbeta; PA28beta; PA28-beta; PA28 beta
• Gene ID: 5721
• mRNA Refseq: NM_002818
• Protein Refseq: NP_002809
• UniProt ID: Q9UL46